Translational_Unit

Part:BBa_K3522007

Designed by: Kong Yangyang   Group: iGEM20_NOFLS_YZ   (2020-10-17)


CMV-FXRα-SV40

FXR agonists can improve blood sugar levels by increasing insulin sensitivity. However, long-term use of FXR can cause some side effects, such as lowering high-density lipoprotein (HDL) levels and increasing obesity. Antagonizing FXR can reduce weight and blood sugar, especially for better control of postprandial blood sugar. Therefore, the research of FXR antagonists is also one of the hot spots of anti-metabolic diseases. We expressed FXR in 293T cells to build a platform for screening small molecule FXR antagonists.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


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Categories
Parameters
None