RNA

Part:BBa_K2050424

Designed by: Muhammad Farhan Maruli   Group: iGEM16_UI-Indonesia   (2016-10-14)


Adenoviral VA1 RNA gene

The VA1 RNA gene is an RNA polymerase III-driven gene that encodes the viral RNA VA1. By its nature, the RNA molecule facilitates infection by inhibiting the protein kinase R response, which is activated in infected cells and acts to globally suppress gene expression to inhibit viral replication. Co-expressing the VA1 RNA gene with a desired non-coding RNA gene allows for the expression of the desired RNA molecule, which would generally trigger PKR response, without sacrificing RNA polymerase II transcription.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


[edit]
Categories
Parameters
None