Coding

Part:BBa_K364308:Experience

Designed by: Bence Daniel   Group: iGEM10_Debrecen-Hungary   (2010-09-28)
Revision as of 22:17, 24 October 2010 by Lityupix (Talk | contribs) (→‎Potential applications)

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Physiological effets of PXR

Like other type II nuclear receptors, when activated, it forms a heterodimer with the retinoid X receptor, and binds to hormone response elements on DNA which elicits expression of gene products.

One of the primary targets of PXR activation is the induction of CYP3A4, an important phase I oxidative enzyme that is responsible for the metabolism of many drugs. In addition, PXR up regulates the expression of phase II conjugating enzymes such as glutathione S-transferase and phase III transport uptake and efflux proteins such as OATP2 (SLCO2A1)and MDR1(ABCB1).

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UNIQ9c0e9080ce1015a6-partinfo-00000000-QINU UNIQ9c0e9080ce1015a6-partinfo-00000001-QINU