Coding
Part:BBa_K5378007
Designed by: pan zhao Group: iGEM24_SMU-GDMU-CHINA (2024-09-25)
feaR-A81L
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
Usage and Biology
FeaR is an AraC family regulator that activates transcription of the tynA and feaB genes in Escherichia coli.FeaR-A81L was identified as PEA-specific variantss, with 580-fold induction.In our project, FeaR-A81L binds to phenylacetaldehyde (PAG) and induces the expression from PtynA.
Functional Verification
Reference
[1]Rottinghaus, A. G., Xi, C., Amrofell, M. B., Yi, H., & Moon, T. S. (2022). Engineering ligand-specific biosensors for aromatic amino acids and neurochemicals. Cell systems, 13(3), 204-214.
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Categories
Parameters
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