Part:BBa_K5499007
LAMP2A mature peptide
Lysosome-associated membrane protein type 2A (LAMP2A) is a crucial protein involved in exosome formation.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
Profile
Name: LAMP2A (Lysosomal-associated membrane protein 2A) mature peptide
Base Pairs:1146 bp
Origins: The LAMP2A mature peptide is derived from the lysosomal-associated membrane protein 2 (LAMP2) gene in mammals. It is processed from the precursor protein after the signal peptide is cleaved.
Properties: LAMP2A's structure facilitates its ability to promote the selective recognition and transport of cytoplasmic proteins containing specific targeting motifs, such as the KFERQ sequence.
Usage and Biology
LAMP2A is involved in recognizing proteins destined for degradation or exosomal secretion by binding to the chaperone-protein complex at the lysosomal membrane. Upon binding, it facilitates the translocation of these proteins into the lysosome for degradation or packaging into multivesicular bodies (MVBs) for exosomal secretion. The interaction between LAMP2A and the KFERQ-like motifs allows for the selective uptake of proteins, ensuring that unwanted or misfolded proteins are efficiently handled by the cell.This positions LAMP2A as a key player in the regulation of protein sorting within cells and the modulation of extracellular signaling through exosomes.
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