Part:BBa_K5499007
LAMP2A mature peptide
Lysosome-associated membrane protein 2, isoform A (LAMP2A), serves as a receptor and channel for transporting cytosolic proteins.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
Profile
Name: LAMP2A Mature Peptide
Base Pairs:1146 bp
Origins: The LAMP2A mature peptide is derived from the lysosomal-associated membrane protein 2 (LAMP2) gene in mammals. It is processed from the precursor protein after the signal peptide is cleaved.
Properties: The LAMP2A mature peptide plays a crucial role in lysosomal function, particularly in chaperone-mediated autophagy (CMA). It facilitates the recognition and translocation of specific cytosolic proteins into the lysosome for degradation. This peptide is characterized by its ability to interact with various proteins and is integral to maintaining cellular homeostasis and regulating lysosomal pathways.
Usage and Biology
The LAMP2A mature peptide is utilized in various biotechnological and therapeutic applications, particularly in the field of gene therapy and lysosomal enzyme replacement therapies. Its ability to mediate the delivery of proteins to lysosomes makes it valuable for treating lysosomal storage disorders and enhancing the clearance of aggregated proteins in neurodegenerative diseases.
The LAMP2A mature peptide is an essential component of the lysosomal membrane and plays a pivotal role in chaperone-mediated autophagy (CMA). By facilitating the selective uptake of cytosolic proteins into the lysosome, it helps maintain cellular homeostasis. The LAMP2A-mediated pathway is critical for the degradation of damaged or misfolded proteins, thereby preventing cellular toxicity. Understanding the biology of LAMP2A is important for developing strategies to manipulate lysosomal function in various diseases.
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