Coding

Part:BBa_K5531012

Designed by: XI ZHAO   Group: iGEM24_SubCat-Union   (2024-09-09)
Revision as of 04:06, 30 September 2024 by Zmy0227 (Talk | contribs)

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P4H


Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]

BBa_K5531012 (P4H)

BBa_K5531012 (P4H)

Profile

Name: P4H
Base Pairs: 738 bp
Origin: Arabidopsis thaliana (Mouse-ear cress); synthesized
Properties: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in proline-rich peptide sequences of plant glycoproteins and other proteins. Hydroxylates preferentially prolines in the second positions in the -Pro-Pro-Gly-triplets. Hydroxyprolines are essential constituents of many plant cell wall glycoproteins, such as extensions, hydroxyproline-rich glycoproteins, lectins, and arabinogalactan proteins. Can hydroxylate collagen-like peptides and hypoxia-inducible transcription factor peptides [1].

Figure 1: Protein structure diagram of P4H
Fig. 1. Protein structure diagram of P4H

References

[1] Rutschmann C, Baumann S, Cabalzar J, Luther KB, Hennet T. Recombinant expression of hydroxylated human collagen in Escherichia coli. Appl Microbiol Biotechnol. 2014 May;98(10):4445-55.

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