Part:BBa_K5477035
UDPD-pGAL1/10-UGT2B15 detox module against BPA
UGT2B15 (UDP-glucuronosyltransferase 2B15) is an enzyme belonging to the UDP-glucuronosyltransferase (UGT) family, which plays a role in the phase II metabolism of xenobiotics and endogenous compounds. UGT2B15 is primarily involved in the process of glucuronidation, a biochemical reaction where glucuronic acid is transferred to lipophilic molecules, making them more water-soluble and easier to excrete from the body. This detoxification process is essential for eliminating harmful substances such as drugs, environmental toxins, and metabolic byproducts. In particular, UGT2B15 is responsible for the glucuronidation of a wide range of compounds, including bisphenol A (BPA), steroid hormones (like androgens), and pharmaceuticals. By conjugating these substances with glucuronic acid, UGT2B15 facilitates their removal via urine or bile, reducing their biological activity and toxicity. The enzyme is expressed predominantly in the liver but is also found in other tissues such as the kidney, prostate, and gastrointestinal tract, where it participates in localized detoxification processes (1).
By incorporating UGT2B15 into the detoxification system, the goal is to metabolize BPA through glucuronidation, rendering it less harmful and easier to excrete from the cell or organism.
Sequence and Features
- 10INCOMPATIBLE WITH RFC[10]Illegal EcoRI site found at 3466
Illegal PstI site found at 542 - 12INCOMPATIBLE WITH RFC[12]Illegal EcoRI site found at 3466
Illegal PstI site found at 542 - 21INCOMPATIBLE WITH RFC[21]Illegal EcoRI site found at 3466
Illegal BglII site found at 1122
Illegal BamHI site found at 3286
Illegal BamHI site found at 3580 - 23INCOMPATIBLE WITH RFC[23]Illegal EcoRI site found at 3466
Illegal PstI site found at 542 - 25INCOMPATIBLE WITH RFC[25]Illegal EcoRI site found at 3466
Illegal PstI site found at 542
Illegal AgeI site found at 1828 - 1000COMPATIBLE WITH RFC[1000]
References
1. Ramírez, Viviana & Gálvez Ontiveros, Yolanda & Porras, Patricia & Martinez-Gonzalez, Luis & Rivas, Ana & Alvarez-Cubero, María. (2021). METABOLIC pathways, alterations in MIRNAS expression and effects of genetic polymorphisms of bisphenol a analogues: A SYSTEMATIC review. Environmental Research. 197. 111062. 10.1016/j.envres.2021.111062.
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