Coding

Part:BBa_K5499002

Designed by: Hongjing Wang   Group: iGEM24_NWU-CHINA-A   (2024-09-28)
Revision as of 18:09, 28 September 2024 by Registry (Talk | contribs)

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Iduronate-2-sulfatase (IDS)

Iduronate-2-sulfatase (IDS) is a lysosomal enzyme that splits the sulfate group in the C-2 positions from iduronic acid residues present in the mucopolysaccharides dermatan sulfate and heparan sulfate. A Deficiency in this enzyme results in the accumulation of these glycosaminoglycans in the lysosomes and subsequently leads to the development of Hunter syndrome(or mucopolysaccharidosis type 2 ) in humans. The disorder is inherited as an X-linked recessive disease and has a broad spectrum of clinical phenotypes ranging from mild to severe forms. This heterogeneity has been postulated to reflect the presence of different mutations in the IDS gene.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


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Categories
Parameters
None