Part:BBa_K5477017
UGT1A1 - UDP-glucuronosyltransferase 1A1
UGT1A1 (UDP-glucuronosyltransferase 1A1) plays a crucial role in the detoxification of environmental pollutants such as dioxins, polycyclic aromatic hydrocarbons (PAHs), and polychlorinated biphenyls (PCBs) through glucuronidation, a process where glucuronic acid is added to lipophilic molecules, increasing their solubility. This reaction converts these toxic compounds into more hydrophilic metabolites, making them easier to excrete via bile or urine. By metabolizing dioxins, PAHs, and PCBs, UGT1A1 helps reduce their toxicity and potential to cause cellular damage, particularly within the liver (1).
Incorporating UGT1A1 into our detoxification system together with UDPD helps detoxify these compounds. The following composites and devices, where this part was used, are listed below:
Sequence and Features
- 10INCOMPATIBLE WITH RFC[10]Illegal EcoRI site found at 706
Illegal PstI site found at 148
Illegal PstI site found at 316
Illegal PstI site found at 619 - 12INCOMPATIBLE WITH RFC[12]Illegal EcoRI site found at 706
Illegal PstI site found at 148
Illegal PstI site found at 316
Illegal PstI site found at 619 - 21INCOMPATIBLE WITH RFC[21]Illegal EcoRI site found at 706
- 23INCOMPATIBLE WITH RFC[23]Illegal EcoRI site found at 706
Illegal PstI site found at 148
Illegal PstI site found at 316
Illegal PstI site found at 619 - 25INCOMPATIBLE WITH RFC[25]Illegal EcoRI site found at 706
Illegal PstI site found at 148
Illegal PstI site found at 316
Illegal PstI site found at 619 - 1000COMPATIBLE WITH RFC[1000]
References
1. Inui H, Itoh T, Yamamoto K, Ikushiro S, Sakaki T. Mammalian cytochrome P450-dependent metabolism of polychlorinated dibenzo-p-dioxins and coplanar polychlorinated biphenyls. Int J Mol Sci. 2014 Aug 13;15(8):14044-57. doi: 10.3390/ijms150814044. PMID: 25123135; PMCID: PMC4159838.
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