Part:BBa_K5477015
LexA-ERRγ Chimeric activator with LexA DNA binding domain fused with LBD of ERRγ
The LexA-ERRγ (LexA-Estrogen-Related Receptor Gamma) fusion protein combines the DNA-binding domain (DBD) of the LexA repressor with the ligand-binding domain (LBD) of Estrogen-Related Receptor Gamma (ERRγ), a member of the orphan nuclear receptor family. ERRγ is classified as an orphan receptor because, unlike classic nuclear receptors, it does not have a well-characterized endogenous ligand. Instead, it functions in a ligand-independent manner or is activated by synthetic or environmental ligands, allowing it to regulate a broad range of physiological processes, including energy metabolism, mitochondrial function, and cellular differentiation.
Sequence and Features
- 10INCOMPATIBLE WITH RFC[10]Illegal PstI site found at 856
Illegal PstI site found at 1003
Illegal PstI site found at 1150 - 12INCOMPATIBLE WITH RFC[12]Illegal PstI site found at 856
Illegal PstI site found at 1003
Illegal PstI site found at 1150 - 21INCOMPATIBLE WITH RFC[21]Illegal BglII site found at 698
- 23INCOMPATIBLE WITH RFC[23]Illegal PstI site found at 856
Illegal PstI site found at 1003
Illegal PstI site found at 1150 - 25INCOMPATIBLE WITH RFC[25]Illegal PstI site found at 856
Illegal PstI site found at 1003
Illegal PstI site found at 1150 - 1000COMPATIBLE WITH RFC[1000]
None |