Coding

Part:BBa_K5477012

Designed by: Kate Malana Escobar   Group: iGEM24_UCopenhagen   (2024-09-26)
Revision as of 15:04, 26 September 2024 by Registry (Talk | contribs)

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NCOA - Nuclear receptor coactivator (Steroid Receptor Coactivator)

Nuclear receptor coactivator (NCOA), also known as SRC (Steroid Receptor Coactivator), is a member of a family of transcriptional coactivators that enhance the activity of nuclear receptors. NCOA plays a pivotal role in regulating gene expression by acting as a bridge between nuclear receptors, such as the Aryl hydrocarbon receptor (AhR). When nuclear receptors are activated by their ligands, NCOA is recruited to the receptor complex, where it interacts with histone acetyltransferases (HATs) and other chromatin-modifying enzymes to promote an open chromatin structure, facilitating transcriptional activation.


Sequence and Features


Assembly Compatibility:
  • 10
    INCOMPATIBLE WITH RFC[10]
    Illegal EcoRI site found at 1079
    Illegal EcoRI site found at 1701
    Illegal SpeI site found at 528
    Illegal SpeI site found at 829
    Illegal SpeI site found at 1896
    Illegal PstI site found at 588
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal EcoRI site found at 1079
    Illegal EcoRI site found at 1701
    Illegal NheI site found at 2841
    Illegal SpeI site found at 528
    Illegal SpeI site found at 829
    Illegal SpeI site found at 1896
    Illegal PstI site found at 588
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal EcoRI site found at 1079
    Illegal EcoRI site found at 1701
    Illegal BamHI site found at 2343
  • 23
    INCOMPATIBLE WITH RFC[23]
    Illegal EcoRI site found at 1079
    Illegal EcoRI site found at 1701
    Illegal SpeI site found at 528
    Illegal SpeI site found at 829
    Illegal SpeI site found at 1896
    Illegal PstI site found at 588
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal EcoRI site found at 1079
    Illegal EcoRI site found at 1701
    Illegal SpeI site found at 528
    Illegal SpeI site found at 829
    Illegal SpeI site found at 1896
    Illegal PstI site found at 588
  • 1000
    COMPATIBLE WITH RFC[1000]


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Categories
Parameters
None