Coding
Part:BBa_K5477012
Designed by: Kate Malana Escobar Group: iGEM24_UCopenhagen (2024-09-26)
NCOA - Nuclear receptor coactivator (Steroid Receptor Coactivator)
Nuclear receptor coactivator (NCOA), also known as SRC (Steroid Receptor Coactivator), is a member of a family of transcriptional coactivators that enhance the activity of nuclear receptors. NCOA plays a pivotal role in regulating gene expression by acting as a bridge between nuclear receptors, such as the Aryl hydrocarbon receptor (AhR). When nuclear receptors are activated by their ligands, NCOA is recruited to the receptor complex, where it interacts with histone acetyltransferases (HATs) and other chromatin-modifying enzymes to promote an open chromatin structure, facilitating transcriptional activation.
Sequence and Features
Assembly Compatibility:
- 10INCOMPATIBLE WITH RFC[10]Illegal EcoRI site found at 1079
Illegal EcoRI site found at 1701
Illegal SpeI site found at 528
Illegal SpeI site found at 829
Illegal SpeI site found at 1896
Illegal PstI site found at 588 - 12INCOMPATIBLE WITH RFC[12]Illegal EcoRI site found at 1079
Illegal EcoRI site found at 1701
Illegal NheI site found at 2841
Illegal SpeI site found at 528
Illegal SpeI site found at 829
Illegal SpeI site found at 1896
Illegal PstI site found at 588 - 21INCOMPATIBLE WITH RFC[21]Illegal EcoRI site found at 1079
Illegal EcoRI site found at 1701
Illegal BamHI site found at 2343 - 23INCOMPATIBLE WITH RFC[23]Illegal EcoRI site found at 1079
Illegal EcoRI site found at 1701
Illegal SpeI site found at 528
Illegal SpeI site found at 829
Illegal SpeI site found at 1896
Illegal PstI site found at 588 - 25INCOMPATIBLE WITH RFC[25]Illegal EcoRI site found at 1079
Illegal EcoRI site found at 1701
Illegal SpeI site found at 528
Illegal SpeI site found at 829
Illegal SpeI site found at 1896
Illegal PstI site found at 588 - 1000COMPATIBLE WITH RFC[1000]
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Categories
Parameters
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