Part:BBa_K137007

fimE

fimE gene

CUHK-HongKong-SBS 2024

In Escherichia coli, FimB, together with FimE, acts as a recombinase that catalyzes the site-specific recombination essential for the inversion of a 314-bp invertible DNA element called the fim switch (fimS). This mechanism is crucial for controlling the transcription of the type I fimbrial structural genes, fimA, in a process known as phase-variation switching (1). The fimS element contains the promoter that drives the expression of these structural genes, whereas FimE is responsible for deactivating fimA (2).

References

National Library of Medicine. (2024). fimB Type 1 fimbriae regulatory protein FimB [Escherichia coli str. K-12 substr. MG1655] - Gene - NCBI. Nih.gov. https://www.ncbi.nlm.nih.gov/gene/948832

UniProt. (2024). P0ADH7 · FIME_ECOLI. Uniprot.org. https://www.uniprot.org/uniprotkb/P0ADH7/entry

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  COMPATIBLE WITH RFC[21]
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  COMPATIBLE WITH RFC[1000]