Generator

Part:BBa_K237002

Designed by: Marc T. K. Nielsen   Group: iGEM09_SDU-Denmark   (2009-08-03)
Revision as of 07:27, 21 October 2009 by Marc.mtk (Talk | contribs)

Constitutive RIP Generator. RIP - Quorum sensing inhibitor of Staphylococcus spp.

RIP or RNAIII inhibiting peptide is a heptapeptide capable of severely reducing the Qourum sensing(QS) abilities of Staphylococcus species [1]. RIP effectively works as an antibiotic in its inhibition of bacterial biofilm-formation. It is important to note that even though it has the effect of an antibiotic [1] on bacterial load, the mechanism is a novel one, and doesn't appear to induce bacterial resistance [1].

RIP has the sequence YSPXTNF and has been tested extensively in a synthetic (as in chemical synthesis) form for ability to inhibit bacterial infections in mice [1] and biofilm formation on human cells [2].


Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


[edit]
Categories
Parameters
None