Coding

Part:BBa_K5198000

Designed by: Duke iGEM   Group: iGEM24_Duke   (2024-08-20)
Revision as of 07:35, 25 August 2024 by Rk320 (Talk | contribs)


CD19ecto

Ectodomain of human CD19 coreceptor. In its native form, CD19 is a coreceptor in the B-cell antigen receptor complex on B-lymphocytes. CD19 is used as a marker of B-cell development and is one of the most popular targets in cell therapies treating most types of leukemia. This part can be used as a soluble ligand that triggers activation of receptors capable of dimerization. CD19ecto has been shown to exist in monomeric and dimeric form. The dimer form is suggested to be responsible for activation of receptors.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal BsaI.rc site found at 225
    Illegal SapI.rc site found at 61


References

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Categories
Parameters
None