Coding

Part:BBa_K5387000

Designed by: iGEM24_Linkoping   Group: iGEM24_Linkoping   (2024-08-20)
Revision as of 08:43, 20 August 2024 by Feliciawedlund (Talk | contribs)

ALOX12B

Description

ALOX12B encodes for the protein Arachidonate 12-lipoxygenase, 12R-type. The primary function of Arachidonate 12-lipoxygenase, 12R-type, in the skin is the catalysis of the oxidation of linoleoyl moiety on O-linoleoyl-ω-hydroxy ceramide to form 9R-hydroperoxy- linoleoyl-ω-hydroxyceramide, a critical process in the formation of the corneocyte lipid envelope in mammalian skin [1]. 

The gene codes for one of the enzymes used for iGEM24_Linkoping substitution therapy for Ichthyosis.

Sequence


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal NheI site found at 1789
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal BglII site found at 722
    Illegal BamHI site found at 2070
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal AgeI site found at 1747
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal BsaI site found at 454

References

https://www.sciencedirect.com/science/article/pii/S0753332220305473#sec0010 UTFÖRLIGARE

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Categories
Parameters
None