Part:BBa_K4989011

Complete butyrate producing gene cluster

Short Description

In this registry page, we will present our New Improved Part that our team created to be nominated for the gold medal in the iGEM 2023 competition! We designed a whole composite part, with its coding and regulatory sequences, that can potentially produce butyrate, a Short Chain Fatty Acid (SCFA) that could potentially treat depression.

The fundaments of the improvement

To result in the design of our new improved part, we needed to find a corresponding part that requires such changes that would not change the function of the part and the general aim of its initial formation but enhance the overall performance.
Team NRP-UEA-Norwich 2015 designed the <a href="https://parts.igem.org/Part:BBa_K1618021">BBa_K1618021</a> composite part that could potentially produce butyrate. We reviewed the part and we realized that it is our ideal candidate to enhance its features and produce a stronger gene cluster of the butyrate production pathway.
Simultaneously, we conducted extensive bibliographic research and we created a draft of the ideal gene cluster and its regulatory elements. In this way, we could compare the ideal draft of the part that we envisioned with the part that was pruned to be improved.