Coding

Part:BBa_K4880001

Designed by: Xinran Xia   Group: iGEM23_BASIS-China   (2023-08-25)
Revision as of 09:58, 12 October 2023 by Aeolus (Talk | contribs) (Santalene)


SaSS

This gene encodes for the santalene synthase derived from Santalum album. This sesquiterpene synthase converts farnesyl pyrophosphate to santalene.

Santalene

Santalene and its derivative Santalol(which has an additional oxygen, forming a hydroxyl group), is an organic chemical with formula of C15H24(C15H24O for Santalol), and is a pale yellow, slightly water soluble compound with a jaw-dropping market value of about 150,000 USD per Kilogram. The fragrance is woody (since it comes from the heartwood of Tropical Sandalwood) and is commonly used in Aromatherapy to prevent inflammation. It is also noted for its ability to induce cell apoptosis for cancer cells. However, as the high price tag might have implied already, the sandalwood tree which the fragrance comes from is extremely endangered: 175 years of commercial harvesting, grazing of saplings by livestock, climate change and poaching may have decreased the population of wild sandalwood by as much as 90%.


Sequence and Features


Assembly Compatibility:
  • 10
    INCOMPATIBLE WITH RFC[10]
    Illegal PstI site found at 862
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal PstI site found at 862
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    INCOMPATIBLE WITH RFC[23]
    Illegal PstI site found at 862
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal PstI site found at 862
    Illegal AgeI site found at 823
    Illegal AgeI site found at 1462
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal BsaI site found at 1257


References

Blanc-Garin V, Chenebault C, Diaz-Santos E, Vincent M, Sassi JF, Cassier-Chauvat C, Chauvat F. Exploring the potential of the model cyanobacterium Synechocystis PCC 6803 for the photosynthetic production of various high-value terpenes. Biotechnol Biofuels Bioprod. 2022 Oct 14;15(1):110.

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