Coding

Part:BBa_K5001001

Designed by: Lan Haishan   Group: iGEM23_GEC-Guangzhou   (2023-10-11)
Revision as of 14:32, 11 October 2023 by Registry (Talk | contribs)

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cytidine deaminase

Since the chemotherapy drug 5-FU is harmful to other normal cells in the human body, while 5-FC is harmless, we have decided to convert 5-FC into 5-FU in the intestines. Therefore, through genetic engineering technology, we have enabled E. coli Rosetta to express CDase. In the intestines, cytosine deaminase (CD) converts a non-toxic prodrug, 5-fluorocytosine (5-FC), into a toxic chemotherapy drug, 5-fluorouracil (5-FU), reducing the harm of 5-FU to the human body.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


[edit]
Categories
Parameters
None