Part:BBa_K4989003
Butyrylo-CoA dehydrogenase (bcd)
It is an improved basic part of:
BBa_K1618043 of iGEM 2015 NRP-UEA-Norwich.
Alternative names of the enzyme
Other names that the butyryl-CoA dehydrogease enzyme could be found in the bibliography are:
Systematic name: short-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
Else: short-chain acyl-CoA dehydrogenase,
butyryl-CoA dehydrogenase,
butanoyl-CoA dehydrogenase,
butyryl dehydrogenase,
unsaturated acyl-CoA reductase,
ethylene reductase,
enoyl-coenzyme A reductase,
unsaturated acyl coenzyme A reductase,
butyryl coenzyme A dehydrogenase,
short-chain acyl CoA dehydrogenase,
short-chain acyl-coenzyme A dehydrogenase,
3-hydroxyacyl CoA reductase,
butanoyl-CoA:(acceptor) 2,3-oxidoreductase,
ACADS (gene name)
Application in the field of biology
The bcd gene encodes for a flavoprotein oxidoreductase that has great specificity for short-chain fatty acids: butyryl-CoA dehydrogenase. The enzyme catalyzes the a and b desaturation of acyl-CoA substrates[1]. This enzyme doesn’t utilize NAD(H) directly but requires electron transfer flavoproteins to form a complex and transfer electrons from butyryl-CoA dehydrogenase to NAD(H)[2].
The full reaction is shown below:
2 NADH+2Fdox + crotonyl−CoA↔2 NAD+2 Fdred+ butyryl−CoA
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