Part:BBa_K4665175

GGGGS linker

This is a flexible linker made of 4 glycine repeats followed by a serine amino acid, typically used for attaching two protein domains of a fusion protein. The glycine-serine linker incorporates both flexible and hydrophilic elements, preventing the formation of secondary structures and reducing the chance that the linker will interfere with the folding and function of the connected protein domains (van Rosmalen et al., 2017).

References

Van Rosmalen, M. M., Krom, M., & Merkx, M. (2017). Tuning the Flexibility of Glycine-Serine Linkers To Allow Rational Design of Multidomain Proteins. Biochemistry, 56(50), 6565–6574. https://doi.org/10.1021/acs.biochem.7b00902