Coding

Part:BBa_K4586030

Designed by: Mohamed Mohamed Saad Aboelghare   Group: iGEM23_AFCM-Egypt   (2023-10-02)
Revision as of 16:37, 2 October 2023 by Mohamed-Ab0elghare (Talk | contribs)


Citrullinated vimentin

Description

Theses are synthetic citrullinated peptide designed to detect anti specific antibodies that are elevated in autoimmune diseases especially rheumatoid arthritis.

Usage

We initially used this part inn our design to be the ligand binding domain in the the extracellular part of our Syn notch receptor to interact with the auto-reactive B-cell receptor that secrete ACPA and transmit the signal of this selective binding inside the cell to express our therapeutic cargo within the modified exosomes that target the auto reactive B-cells.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


[edit]
Categories
Parameters
None