RNA

Part:BBa_K4586006

Designed by: Mohamed Mohamed Saad Aboelghare   Group: iGEM23_AFCM-Egypt   (2023-09-15)
Revision as of 12:24, 20 September 2023 by Mahmoud sayed (Talk | contribs) (→‎Part Description)


Guide RNA

Part Description

Our guide RNA part is a specific RNA fragment that navigates the Cas system to the RNA or DNA target of interest according to its family and serves to make some changes, such as deletion, insertion, or alteration, to the target RNA or DNA by building complexes with them.

Usage

Our guide RNA is designed to drive the activity of the Cas12k protein toward the target gene, which is the B-cell activating factor receptor (BAFF-R) gene, as knocking down this gene will affect the survival of the autoreactive B-cells and limit its pathogenic effect in RA

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


[edit]
Categories
Parameters
None