Coding

Part:BBa_K4429007

Designed by: Anish Mulchandani   Group: iGEM22_IISER-Pune2_India   (2022-07-22)
Revision as of 03:20, 14 October 2022 by Anishmulchandani (Talk | contribs)

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scFv513: EDIII

This part codes for the scFv version of the Ab513 antibody. Ab513 is an antibody that targets the Envelope Protein Domain III (EDIII) of the Dengue virus[1]. Ab513 is a highly potent, pan-neutralising antibody against Dengue. An scFv is an antibody fragment that consists of just the variable regions of the antibody connected by a flexible linker. Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


References

  • 1] Robinson, L. N., Tharakaraman, K., Rowley, K. J., Costa, V. V., Chan, K. R., Wong, Y. H., Ong, L. C., Tan, H. C., Koch, T., Cain, D., Kirloskar, R., Viswanathan, K., Liew, C. W., Tissire, H., Ramakrishnan, B., Myette, J. R., Babcock, G. J., Sasisekharan, V., Alonso, S., Chen, J., … Sasisekharan, R. (2015). Structure-Guided Design of an Anti-dengue Antibody Directed to a Non-immunodominant Epitope. Cell, 162(3), 493–504. https://doi.org/10.1016/j.cell.2015.06.057
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