Part:BBa_K4165186
Amyloid β Peptide 6 (Aβ 39-42)
This part encodes a part of the Amyloid 𝛽 fragment (39-42) which has the ability to bind to A𝛽 plaques inside the brain.
Usage and Biology
Segments of amyloid beta fibrils are widely used as a recognition sequence for amyloid beta plaques inside the brain, this is due to the homotypic interactions in the C-terminus of fibrils.
This peptide was one of the higher acting regarding the inhibitory effect of Aβ oligomers, it is proved to reduce toxicity of the oligomers by converting them into a nontoxic form. Moreover, its small size may facilitate its use in different modified drugs for AD.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
Dry Lab Characterization
Modeling
The peptide was modeled by several software (Alphafold-Apptest-Pepfold) and the best model from Alphafold scored 3 out of 6 according to our Quality assessment code.
Figure 1. The 3D structure of peptide AB (39-42) modeled by Alphafold
References
Fradinger, E., Monien, B., Urbanc, B., Lomakin, A., Tan, M., & Li, H. et al. (2008). C-terminal peptides coassemble into Aβ42 oligomers and protect neurons against Aβ42-induced neurotoxicity. Proceedings Of The National Academy Of Sciences, 105(37), 14175-14180. doi: 10.1073/pnas.0807163105
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