Coding

Part:BBa_K4156085

Designed by: Zheng Huang   Group: iGEM22_LZU-CHINA   (2022-10-06)
Revision as of 11:49, 11 October 2022 by Hz (Talk | contribs)

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CDD-iRGD

CDD-IRGD is Bit1 cell death domain fusion protein with tumour perforator protein.


Usage and Biology

CDD-iRGD activates the host immune response and triggers apoptosis of tumour cells. iRGD tumor-penetrating peptide-modified lysing adenovirus shows enhanced tumor transmission, intra-tumor dissemination and anti-tumor efficacy.

CDD-iRGD activates host immune response and triggers apoptosis of tumor cells. the protein is expressed with the constitutive promoter plac, thus exerting an anti-tumor effect. Therefore, we plan to use CDD-IRGD as a tumor treatment factor[1].

References

1 Chen R, Braun GB, Luo X, Sugahara KN, Teesalu T, Ruoslahti E. Application of a proapoptotic peptide to intratumorally spreading cancer therapy. Cancer Res. Feb 15 2013;73(4):1352-61. doi:10.1158/0008-5472.Can-12-1979

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


[edit]
Categories
Parameters
None