Part:BBa_K4165139
TLKIVW Peptide
A synthetic peptide that is used for targeting misfolded tau protein (BBa_K4165009) as it binds to PHF6 of tau fibrils.
Usage and Biology
TLKIVW is a hexapeptide designed using Rosetta software and obtained by phage display to bind to VQIVYK (BBa_K4165204) steric zipper motif of tau fibers, which is from the main reasons of the Alzheimer’s disease and other dementia related diseases, this peptide can also prevent further accumulation of tau fibrils.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
Dry Lab
Modeling
TLKIVW was modeled by AlphaFold2 and Apptest and the best model was obtained from Apptest ranking 5 out of 6 according to our quality assessment code.
| cbeta_deviations | molprobity | ramachandran_favored | ramachandran_outliers | Qmean_4 | Qmean_6 |
|---|---|---|---|---|---|
| 0 | 2.11 | 100 | 0 | -1.97474 | -0.69185 |
Figure 1: Predicted 3D structure of Synthetic peptide TLKIVW.
Table 1: Quality assessment parameters of TLKIVW model.
References
1. Sievers, S. A., Karanicolas, J., Chang, H. W., Zhao, A., Jiang, L., Zirafi, O., ... & Eisenberg, D. (2011). Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation. Nature, 475(7354), 96-100.
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