Part:BBa_K4165005
Amyloid β Protein Fragment 1-42 (Aβ 1-42)
Amyloid β Protein Fragment 1-42 which results from the amyloidogenic degradation of Amyloid beta precursor and forms toxic plaques inside the brain leading to the development of Alzheimer's Disease.
Usage and Biology
A𝛽-42 formation is due to the amyloidogenic degradation of Amyloid Precursor Protein (APP). APP is a normal cell surface receptor whose cleavage results in different types of peptides depending on the method, and those peptides serve different functions. In the amyloidogenic pathway APP is partially cleaved by two enzymes, the first one is 𝛽-secretase which cleaves APP into 𝛽-APP and the second enzyme is 𝛾-secretase responsible for the cleavage of the remaining part of APP to form A𝛽-42 fragments. The 42 amino acid fragments are toxic in nature and form A𝛽 plaques when aggregated together. The plaques block the transmission of electrical impulses and communication between neurons, therefore causing memory loss.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
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