Part:BBa_K4241793

Cecropin B Q53

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  INCOMPATIBLE WITH RFC[21]

  Illegal BamHI site found at 77
  
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  COMPATIBLE WITH RFC[1000]

Overview

Cecropin B isoform Q53 is an enhanced Cecropin B that shows increased antimicrobial ability against bacteria such as P. aeruginosa. This part is derived from the following publication: https://pubmed.ncbi.nlm.nih.gov/31045339/

Usage and Biology

Cecropin B Q53 is a naturally produced antimicrobial peptide isolated from Bombyx mori, this isoform differs from the other isoform E53 by replacing a single peptide; glutamic acid by glutamine. This peptide demonstrates strong antimicrobial properties against gram-negative and gram-positive bacteria. Furthermore, this peptide demonstrates high stability to pH and temperature variations as well as tolerance to high-salt concentration and low-toxicity to human cells.

References

Romoli, O., Mukherjee, S., Mohid, S. A., Dutta, A., Montali, A., Franzolin, E., Brady, D., Zito, F., Bergantino, E., Rampazzo, C., Tettamanti, G., Bhunia, A., & Sandrelli, F. (2019). Enhanced silkworm cecropin B antimicrobial activity against pseudomonas aeruginosa from single amino acid variation. ACS Infectious Diseases, 5(7), 1200–1213. https://doi.org/10.1021/acsinfecdis.9b00042