Protein_Domain

Part:BBa_K4165226

Designed by: Engy Khaled   Group: iGEM22_CU_Egypt   (2022-10-08)
Revision as of 08:02, 8 October 2022 by Engy99 (Talk | contribs) (→‎Usage and Biology)


Linker GGSGG

flexible linker with 5 aa sequence

Usage and Biology

A flexible linker with G and S aa residues with variable lengths. According to our project, 3 flexible linker required one for our clamps for binding of Tau or amyloid beta with our binding paptides . Second one for flexible linking between clamps and HTRA1 binding peptide . last one for binding our HTRA1 binding peptide with PDZ domain of our protease HTRA1. our linker with length [5 aa GGSGGG ] was calculated by our team for testing how it would affect interaction of our mentioned parts with each other using Pymol Software.


Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]

References

1- Yuan, S., Chan, H. S., & Hu, Z. (2017). Using pymol as a platform for computational drug design. WIREs Computational Molecular Science, 7(2). doi:10.1002/wcms.1298


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