Coding

Part:BBa_K4165205

Designed by: Engy Khaled   Group: iGEM22_CU_Egypt   (2022-10-05)
Revision as of 07:45, 7 October 2022 by Engy99 (Talk | contribs) (→‎Usage and Biology)


PHF asteric


Structure of the amyloid-spine from microtubule associated protein tau Repeat 2


Usage and Biology

More than 20 neurological diseases, including Alzheimer's disease, are linked to aggregated tau protein. The major parts derive these aggregations are 2 segments of VQIVYK (BBa_K4165205) and our part VQIINK. Previous Researches proved that VQIINK , located at the start of R2 repeat, is the most powerful one for deriving aggregations so many inhibitors can be designed according to this structure for inhibition of these aggregations.

3D Model

                                           Figure 1.: RCSB Figure of PHF6*


Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


[edit]
Categories
Parameters
None