Part:BBa_K4165015

UBE2W

Ubiquitin-conjugating E2 ligase has a role in the ubiquitination cascade for protein degradation.

Usage and Biology

Inactive RING/U-box type E3s, such lacking the active site cysteine residues to form thioester linkages with ubiquitin, or even the absence of E3 will not prevent UBE2W-catalyzed ubiquitination, albeit at a slow rate.

source

UBE2W: Q96B02 in Uniprot - NP_001001481.3 in NCBI

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  COMPATIBLE WITH RFC[21]
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  COMPATIBLE WITH RFC[1000]

Refrences

1- Komander D. (2009). The emerging complexity of protein ubiquitination. Biochemical Society transactions, 37(Pt 5), 937–953. https://doi.org/10.1042/BST0370937

2- David, Y., Ziv, T., Admon, A., & Navon, A. (2010). The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. The Journal of biological chemistry, 285(12), 8595–8604. https://doi.org/10.1074/jbc.M109.089003