Part:BBa_K4165013

UBE2V2

Ubiquitin-conjugating E2 ligase has a role in the ubiquitination cascade for protein degradation.

Usage and Biology

UBE2V2/UBE2N is a heterodimer that catalyzes the formation of poly-ubiquitin chains that lack the typical Lys-63 linkage. In this case, poly-ubiquitination does not result in proteasomal protein breakdown. Promotes the transcription of target genes. Functions as a regulator of cell cycle progression and differentiation. Helps cells recover from DNA damage by participating in the error-free DNA repair pathway.

Source

UB2V2: Q15819 in Uniprot - NP_00331.1 in NCBI

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  COMPATIBLE WITH RFC[21]
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  COMPATIBLE WITH RFC[1000]

Refrences

1-Komander D. (2009). The emerging complexity of protein ubiquitination. Biochemical Society transactions, 37(Pt 5), 937–953. https://doi.org/10.1042/BST0370937.

2-David, Y., Ziv, T., Admon, A., & Navon, A. (2010). The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. The Journal of biological chemistry, 285(12), 8595–8604. https://doi.org/10.1074/jbc.M109.089003