Coding

Part:BBa_K4165198

Designed by: Esraa Elmligy   Group: iGEM22_CU_Egypt   (2022-10-02)
Revision as of 11:23, 6 October 2022 by Omnia Alaa11 (Talk | contribs)


Amyloid beta peptide 18 (Aβ 38-42)

This part encodes a part of the Amyloid 𝛽 fragment (38-42) which has the ability to bind to A𝛽 plaques inside the brain.

Usage and Biology

Type of Amyloid-beta binding peptide start from amino acid 38 to 42, this peptide characterized by its solubility which is 156 ± 33 μm.

Features and codon optimize

This sequence is optimized for E. coli bacteria

Source

Homo sapiens Amyloid-beta precursor protein - UniProt (P05067)

References

1- Zhao, Y., Cai, J., Liu, Z., Li, Y., Zheng, C., Zheng, Y., ... & Liu, Y. (2018). Nanocomposites inhibit the formation, mitigate the neurotoxicity, and facilitate the removal of β-amyloid aggregates in Alzheimer’s disease mice. Nano letters, 19(2), 674-683.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


[edit]
Categories
Parameters
None