RNA

Part:BBa_K4162005

Designed by: Weiwen Chen   Group: iGEM22_Fudan   (2022-09-29)
Revision as of 08:22, 6 October 2022 by Ted Chen (Talk | contribs)


Hammerhead ribozyme


Introduction

Hammerhead ribozyme was first found in the genome of viruses and viroids. It involved in the processing of RNA transcripts based on rolling-circle replication. The tandem copy of RNA sequence will be generated in the roll ring replication, and the self-cleaving activity of ribozyme can ensure the generation of RNA copy of unit length.[1]

Figure 1. Self-cleaving ribozymes play a role in rolling-circle replication of some Viral and viroid genomes.



Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]



References

  1. ↑ Ferré-D'Amaré, Adrian R, and William G Scott. “Small self-cleaving ribozymes.” Cold Spring Harbor perspectives in biology vol. 2,10 (2010): a003574. doi:10.1101/cshperspect.a003574
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