Part:BBa_K4268000
S-TIP37 Head-Tail Connector
Usage and Biology
S-TIP 37 is a T7-like cyanophage that virally infects its host via a lytic life cycle. T7-like phages are characterized by a complex symmetrical structure whose major structures are an icosahedral capsid (head) that houses the phage's virus, six tail-like fibers responsible for attachment to its host, and a "neck" region.
This part belongs to a collection that codes for a "ghost" phage shell that can be used to immobilize or deliver substances, to emerging chassis in synthetic biology. It is unclear if the "ghost" phage will be able to infect Synechococcus pcc 11901, a common cyanobacterial engineering chassis. However, it will infect Synechococcus sp WH8109, the cyanobacteria that S-TIP37 infects. Further modeling will be needed to determine if the "ghost" phage could effectively be used in cyanobacterial engineering.
The Head-Tail Connector codes for the "neck" region of a T7-like phage. The "neck" serves two main purposes, binding the icosahedral capsid to the tail-like fibers and containing the molecular machinery that is responsible for injecting its contents into the target cyanobacteria.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12INCOMPATIBLE WITH RFC[12]Illegal NheI site found at 346
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
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