Part:BBa_K4235000
Human Protein S Gene (PROS1)
Sequence and Features
- 10INCOMPATIBLE WITH RFC[10]Illegal EcoRI site found at 2028
Illegal XbaI site found at 1341 - 12INCOMPATIBLE WITH RFC[12]Illegal EcoRI site found at 2028
- 21INCOMPATIBLE WITH RFC[21]Illegal EcoRI site found at 2028
- 23INCOMPATIBLE WITH RFC[23]Illegal EcoRI site found at 2028
Illegal XbaI site found at 1341 - 25INCOMPATIBLE WITH RFC[25]Illegal EcoRI site found at 2028
Illegal XbaI site found at 1341 - 1000COMPATIBLE WITH RFC[1000]
Mutations in this gene (inherited as an autosomal dominant, homozygous or heterozygous fashion) cause non-functional or lower plasma levels of Protein S resulting in a Protein S deficiency. Individuals with Protein S deficiency are at an increased risk of developing abnormal blood clots, specifically in the smaller veins, known as venous thromboembolism. Two most common conditions associated with Protein S deficiency are deep vein thrombosis and pulmonary embolism. Although rare, infants with severe protein S deficiency can develop several blood clots throughout the body, resulting in a life threatening condition known as purpura fulminans. Moreover, severe COVID-19 infections are known to cause a decline in protein S levels, which further contributes to infection severity by causing extensive endothelial dysfunction and lung damage, which is a major cause of COVID-related mortality.
Bioinformatics: (protein modeling info from dry lab analysis)
Characterization and measurements: at least add a pcr gel picture.
Future Direction:
//chassis/eukaryote
| chassis | Spodoptera Frugiperda |