Coding

Part:BBa_K3861010

Designed by: Kristin Funke   Group: iGEM21_Humboldt_Berlin   (2021-10-01)
Revision as of 16:06, 17 October 2021 by Martje1998 (Talk | contribs)


Pep8

Pep8 is an artificial peptide that was shown to play a potential role in the re-induction of p53 translation which leads to decreased tumor growth in mice xenograft (Luccesi et al., 2019). p53 acts as tumor suppressor by preserving the integrity of the genome. p53 loss of function is associated with more than half of all human cancers (Vogelstein et al., 2000; Vousden and Prives, 2009). Further, Pep8 was shown to sensitize cancer cells to an anticancer drug doxorubicin (Luccesi et al, 2019). Pep8 is part of the composite parts BBa_K3861024 and BBa_K3861026.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


[edit]
Categories
Parameters
None