Part:BBa_K3846003
Amorpha-4,11-diene 12-monooxygenase (CYP71AV1)
Involved in the biosynthesis of the antimalarial endoperoxide artemisinin (PubMed:16458889, PubMed:16612385, PubMed:20351109, PubMed:27488942).
Catalyzes three consecutive oxidations of amorpha-4,11-diene to produce artemisinic acid, with artemisinic alcohol and artemisinic aldehyde as intermediates products, but is unable to oxidize germacrene A (PubMed:16458889, PubMed:16612385, PubMed:20351109, PubMed:23246612).
No activity with limonene, alpha-pinene, beta-pinene, pinocarveol, (-)-alloisolongifolene, caryophyllene, (-)-alpha-gurjunene, (+)-gamma-gurjunene, (+)-ledene, (+)-beta-selinene and (+)-valencene as substrates (PubMed:16458889, PubMed:16612385, PubMed:20351109).
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
None |