DNA
HR2-Apt

Part:BBa_K3897000

Designed by: Connor   Group: iGEM21_GreatBay_SCIE   (2021-09-30)
Revision as of 03:23, 2 October 2021 by SoniaPeh (Talk | contribs)


HR2 Aptamer, for targeting HER2 receptors

<h1**Introduction**</h1> HR2 Aptamer is an 86bp ssDNA strand that can be folded into 3D shapes to target Human Epidermal Growth Factor 2 (HER2), which belongs to the Erbb receptor tyrosine kinase family. HER2 is overexpressed in some cases of breast cancer tumor cells, thus many current breast cancer drugs target this receptor either to inhibit this pathway(e.g. Herceptin), bring drugs to it proximity (ADC type drugs), or trigger immune responses (CAR-T). Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


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Parameters
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