Part:BBa_K3710002

Proteus mirabilis encodes the transcriptional regulator UreR of the Urease gene cluster belonging to the AraC/XylS family of transcriptional regulators. UreR upregulates the gene clusters’ subunit transcription and recruits the accessory proteins (UreDABCEFG), when accompanied by urea, to form an active urease [2].

References: [1] Poore, C. and Mobley, H. (2003) "Differential regulation of the Proteus mirabilis urease gene cluster by UreR and H-NS", Microbiology, 149(12), pp. 3383-3394. doi: 10.1099/mic.0.26624-0. [2] Dattelbaum, J. et al. (2003) "UreR, the Transcriptional Activator of the Proteus mirabilis Urease Gene Cluster, Is Required for Urease Activity and Virulence in Experimental Urinary Tract Infections", Infection and Immunity, 71(2), pp. 1026-1030. doi: 10.1128/iai.71.2.1026-1030.2003. [3]. Thomas V, Collins C. Identification of UreR binding sites in the Enterobacteriaceae plasmid-encoded and Proteus mirabilis urease gene operons. Molecular Microbiology. 1999;31(5):1417-1428.