Part:BBa_K3838555
J-LL37
LL-37 is an antimicrobial peptide secreted by human immune cells, which can inhibit harmful bacteria such as Helicobacter pylori and Staphylococcus aureus. At concentrations usually found on adult mucosal surfaces (1-5 μg/ml), the peptide does not play a direct bactericidal role, but participates in immune regulation, and LL-37 protects against endotoxemia/septicemia. At very low concentrations (≤1 μg/ mL) and under physiological salt conditions in vivo, LL-37 has powerful anti-endotoxin properties and can regulate inflammatory response by inhibiting the release of TNF-α in LPS-stimulated human monocytes and reducing LPS-induced transport of P50 / P65 to the nucleus. LL-37 inhibits LPS-induced gene transcription and plays an anti-endotoxin role. In the presence of LPS, LL-37 significantly inhibited the expression of specific pro-inflammatory genes up-regulated by NF-κB. LL37 treatment also significantly changed the species and abundance of intestinal flora in mice, revealing its important effect on intestinal flora.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12INCOMPATIBLE WITH RFC[12]Illegal NheI site found at 7
Illegal NheI site found at 30 - 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
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