Protein_Domain

Part:BBa_K4040003

Designed by: Tong Yin   Group: iGEM21_NMU_China   (2021-09-02)
Revision as of 03:17, 3 September 2021 by Ytong (Talk | contribs)


Intracellular Domain of CD3 zeta chain

The structure and function of CAR ζ:

CAR ζ is another CAR aimed to increase the phagocytosis of the macrophages. And the structure is also similar to the other three CARs, with the difference in the intracellular domain which is replaced by CD ζ subunit of the T cell receptor.

The mechanism of CAR ζ:

The main function domain of the CAR ζ is the cytosolic Immunoreceptor Tyrosine-based Activation Motifs (ITAMs) as mentioned before. When the ligands matches its receptor, the Src family kinases will consequently be phosphorylated and thus activating the cytosolic Immunoreceptor Tyrosine-based Activation Motifs (ITAMs). The further signal pathway is the same as mentioned in CAR-MEGF10.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


[edit]
Categories
Parameters
None