Protein_Domain

Part:BBa_K3672004

Designed by: Mingyao Wang   Group: iGEM20_SCU-WestChina   (2020-10-26)
Revision as of 07:22, 26 October 2020 by Registry (Talk | contribs)

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SILY，collagen I targeting probe

DS-GAG utilized a peptide sequence derived from the collagen I platelet receptor [RRANAALKAGELYKSILYGC (SILY); Kd: 0.86 μM] DS-GAG modulated collagen fibril organization. It is likely that the DS-GAG also had protective effects for collagens against MMP-mediated degradation by blocking MMP binding sites. In addition, DS facilitated cell proliferation by helping FGF receptors dimerize, since N-acetylgalactosamine (GalNAc) and iduronate (IdoA) can interact with FGFs (FGF-2 and FGF-10) and its receptor, FGFR2-IIIb. Further investigation of the original sequence of SILY revealed that only GELYKCILY was responsible for the collagen binding ability

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


[edit]
Categories
Parameters
None