Part:BBa_K3381002
Mst-CopC (copper-binding)
Mst-CopC is a copper binding protein with a single binding site that preferentially binds Cu(II). Published binding affinities for Mst-CopC did not include the variant present in Methylosinus trichosporium; however, our molecular dynamics simulation showed that it had a total interaction energy of -540.64 KJ/mol. This was done with a 10 nanosecond simulation using GROMACS and the Charmm36 force field (Vanommeslaeghe, 2010) (see our engineering and model pages for more information). Mst-CopC binds Cu(II) with a “distorted square pyramidal geometry with H23, H107, D105, and the amino terminus comprising the planar ligands and a water molecule serving as the axial ligand” (Lawton, Kenney, Hurley, & Rosenzweig, 2016).
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
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