Part:BBa_K3132017

human interleukine 15

In order to make the monitoring device has higher sensitivity,IL-15 proteins have high secretory capability. At the same time, to reduce the interference of IL-15 proteins original expression, we fused suntag which had been well characterized in this literature and another generic protein label flag to I-15 proteins, anticipating this device can detect IL-15-tag signal molecules secreted by the core device.

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  COMPATIBLE WITH RFC[21]
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  INCOMPATIBLE WITH RFC[1000]

  Illegal SapI.rc site found at 296
  

MIT_MAHE 2020

Summary

Interleukin-15 (IL-15) is a pleiotropic cytokine with variety of biological functions in many different cell types. It plays a major role in protective immune and inflammatory responses to microbial invaders and parasites. It is involved in modulating immune cells of both the innate and adaptive immune systems. IL-15 is a cytokine with potent survival and immunomodulatory effects on cells of both innate and adaptive immune systems. It has the ability to activate and expand NK cells, NKT cells, CD8+ effector memory and central memory T lymphocytes.

References

1. Perera, P. Y., Lichy, J. H., Waldmann, T. A., & Perera, L. P. (2012). The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use. Microbes and infection, 14(3), 247–261. https://doi.org/10.1016/j.micinf.2011.10.006