Part:BBa_K3450006

Neurogenin 3 (NEUROG3) is a basic helix–loop–helix transcription factor and plays an important role in beta-cell development. It usually forms a homodimer with another basic helix–loop–helix transcription factor and regulate gene expression. NEUROG3 is involved in neurogenesis and the development of embryonic pancreas. The mice lacking NEUROG3 died due to diabetes as they did not have the alpha, beta, delta, and pancreatic polypeptide islet cells along with endocrine precursor cells.[1] Transient expression of PDX1, NEUROG3, and/or MAFA has been successfully used to reprogram intestinal crypt cells into glucose-responsive insulin-producing neoislet cells.[2]

References

[1] Zhu, Y., Liu, Q., Zhou, Z. & Ikeda, Y. PDX1 , Neurogenin-3 , and MAFA : critical transcription regulators for beta cell development and regeneration. 1–7 (2017). doi:10.1186/s13287-017-0694-z https://stemcellres.biomedcentral.com/track/pdf/10.1186/s13287-017-0694-z [2] Chen YJ, Finkbeiner SR, Weinblatt D, Emmett MJ, Tameire F, Yousefi M, Yang C, Maehr R, Zhou Q, Shemer R, Dor Y, Li C, Spence JR, Stanger BZ. De novo formation of insulin-producing "neo-β cell islets" from intestinal crypts. Cell Rep. 2014 Mar 27;6(6):1046-1058. doi: 10.1016/j.celrep.2014.02.013. Epub 2014 Mar 6. PMID: 24613355; PMCID: PMC4245054. https://pubmed.ncbi.nlm.nih.gov/24613355/