Coding

Part:BBa_K3450004

Designed by: Priya Sharma Shashaank G. Prerita Chawla   Group: iGEM20_IISER_Bhopal   (2020-10-23)
Revision as of 17:07, 23 October 2020 by Registry (Talk | contribs)

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Pdx1: A transcription factor required for embryonic development of pancreas

Pancreas/ duodenum homeobox protein 1 (PDX1) or insulin promoter factor 1 is a homeodomain transcription factor. It is involved in transcriptional activation of insulin, somatostatin, islet amyloid polypeptide, glucokinase, and type-2 glucose transporter genes. It is required for early embryonic development of the pancreas and proximal duodenum. It plays an important role in the specification of different endocrine lineages, and maintenance of beta-cell function.[1] Transient expression of PDX1, NEUROG3, and/or MAFA has been successfully used to reprogram intestinal crypt cells into glucose-responsive insulin-producing neoislet cells.[2]


Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal NheI site found at 705
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal XhoI site found at 169
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal NgoMIV site found at 258
    Illegal NgoMIV site found at 285
    Illegal NgoMIV site found at 747
  • 1000
    COMPATIBLE WITH RFC[1000]


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Categories
Parameters
None