Coding

Part:BBa_K3582303

Designed by: Avadhoot Jadhav, Saillesh C   Group: iGEM20_IISER-Pune-India   (2020-10-22)
Revision as of 17:02, 22 October 2020 by Avadhoot (Talk | contribs)

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Inhibitory Peptide sequence 1 for PfRH5-Basigin Interaction

The following characteristic properties are observed in this inhibitory peptide sequence:

  • 1] Interaction energy: -9.15353 kcal/mol
  • 2] Stability value: 4.75382 dG units

This biobrick is able to synthesize the inhibitory peptide which is believed to be able to bind more effectively to PfRH5 as compared to the wild type sequence. The peptide sequence is designed using saturation mutagenesis. Many residues were mutated and it is thought that this change can confer extra stability to the inhibitory peptide as it binds to the parasite protein.


Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


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Categories
Parameters
None