Part:BBa_K3661002

YebF-IL 22

This composite part is composed of the secretion part of YebF and the part of anti-inflammatory factor IL-22.The IL-22 is a natural immunosuppressive protein. We add a secretion tag to increase the extracellular concentration. YebF secretion system is widely used in E.coli.IL-22 can be secreted from our engineered bacteria through this system efficiently. Interleukin-22(IL-22) is a member of a group of the IL-10 family, a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells. IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction. It can initiate and regulate innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells.

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  INCOMPATIBLE WITH RFC[12]

  Illegal NheI site found at 547
  
• 21
  INCOMPATIBLE WITH RFC[21]

  Illegal BglII site found at 108
  
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  COMPATIBLE WITH RFC[1000]